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KMID : 1033620220490010002
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Clinical and Experimental Reproductive Medicine
2022 Volume.49 No. 1 p.2 ~ p.8
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Effects and safety of COVID-19 vaccination on assisted reproductive technology and pregnancy: A comprehensive review and joint statements of the KSRM, the KSRI, and the KOSAR
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Han Ae-Ra
Lee Da-Yong
Kim Seul-Ki
Choo Chang-Woo
Park Joon-Cheol
Lee Jung-Ryeol
Choi Won-Jun
Jun Jin-Hyun
Rhee Jeong-Ho
Kim Seok-Hyun
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Abstract
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Humanity is in the midst of the coronavirus disease 2019 (COVID-19) pandemic, and vaccines?including mRNA vaccines?have been developed at an unprecedented speed. It is necessary to develop guidelines for vaccination for people undergoing treatment with assisted reproductive technology (ART) and for pregnancy-related situations based on the extant laboratory and clinical data. COVID-19 vaccines do not appear to adversely affect gametes, embryos, or implantation; therefore, active vaccination is recommended for women or men who are preparing for ART. The use of intravenous immunoglobulin G (IVIG) for the treatment of immune-related infertility is unlikely to impact the effectiveness of the vaccines, so COVID-19 vaccines can be administered around ART cycles in which IVIG is scheduled. Pregnant women have been proven to be at risk of severe maternal and neonatal complications from COVID-19. It does not appear that COVID-19 vaccines harm pregnant women or fetuses; instead, they have been observed to deliver antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the fetus. Accordingly, it is recommended that pregnant women receive COVID-19 vaccination. There is no rationale for adverse effects, or clinical cases of adverse reactions, in mothers or neonates after COVID-19 vaccination in lactating women. Instead, antibodies to SARS-CoV-2 can be delivered through breast milk. Therefore, breastfeeding mothers should consider vaccination. In summary, active administration of COVID-19 vaccines will help ensure the safe implementation of ART, pregnancy, and breastfeeding.
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KEYWORD
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Assisted reproductive technology, COVID-19, Lactation, Pregnancy, Vaccination
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